MINERALS AND TRACE ELEMENT PROFILE IN DIABETES MELLITUS

The  recognition  of  the  importance  of  trace  elements  in  health  and  disease  has  been  gradually increasing. According to recent studies, these mineral imbalances are related to health problems such as diabetes. Impaired mineral metabolisms are observed in diabetics with complications. In  the present study, minera and trace element profile is evaluated in diabetic subjects and the results showed that even though there was difference in the mineral and trace element status in diabetics compared to healthy controls, the difference was not significant.

 

OXIDATIVE STRESS AND RENAL STATUS IN DIABETES MELLITUS

Oxidative stress is a loss of counter balance between free radical or reactive oxygen species production and the antioxidant systems  which  leads  to the progression of different chronic diseases such as Diabetes mellitus. Oxidative stress in diabetes mellitus has been found increased due to increased protein  glycosylation;  glucose  auto-oxidation;  formation  of  advanced  glycation  end-products  and polyol pathway. In more than 50% of patients with chronic renal failure glucose intolerance is observed due to insulin resistance. The degree of glucose intolerance and insulin resistance correlate directly with the level of serum Creatinine. In the present study, the level of serum lipid peroxidation product, Malondialdehyde (MDA) and Creatinine levels, as a marker of renal status in Diabetic patients are compared with healthy non- diabetic people as controls.  The present study was conducted on 50 diabetic patients, 25 normal non diabetic non lipidemic controls and 25 non diabetic with dislipidemia as controls reporting to MNR Medical College and Hospital, Sangareddy. The results showed that elevated plasma glucose levels correlated with the rise in MDA levels.  The present study also shows that  serum  Creatinine  levels  are  increased  in  diabetics  when  compared  to  controls  of  healthy individuals. These results give support to those studies which considered increased lipid peroxidation is an  important  factor  in  the  pathogenesis  of  Diabetes  leading  to  increased  lipid  peroxide  load  in reflecting the severity of the disease and it also leads to renal insufficiency in this study represented by increased Creatinine levels.