The recognition of the importance of trace elements in health and disease has been gradually increasing. According to recent studies, these mineral imbalances are related to health problems such as diabetes. Impaired mineral metabolisms are observed in diabetics with complications. In the present study, minera and trace element profile is evaluated in diabetic subjects and the results showed that even though there was difference in the mineral and trace element status in diabetics compared to healthy controls, the difference was not significant.
Wednesday 19 December 2012
OXIDATIVE STRESS AND RENAL STATUS IN DIABETES MELLITUS
Oxidative stress is a loss of counter balance between free radical or reactive oxygen species production and the antioxidant systems which leads to the progression of different chronic diseases such as Diabetes mellitus. Oxidative stress in diabetes mellitus has been found increased due to increased protein glycosylation; glucose auto-oxidation; formation of advanced glycation end-products and polyol pathway. In more than 50% of patients with chronic renal failure glucose intolerance is observed due to insulin resistance. The degree of glucose intolerance and insulin resistance correlate directly with the level of serum Creatinine. In the present study, the level of serum lipid peroxidation product, Malondialdehyde (MDA) and Creatinine levels, as a marker of renal status in Diabetic patients are compared with healthy non- diabetic people as controls. The present study was conducted on 50 diabetic patients, 25 normal non diabetic non lipidemic controls and 25 non diabetic with dislipidemia as controls reporting to MNR Medical College and Hospital, Sangareddy. The results showed that elevated plasma glucose levels correlated with the rise in MDA levels. The present study also shows that serum Creatinine levels are increased in diabetics when compared to controls of healthy individuals. These results give support to those studies which considered increased lipid peroxidation is an important factor in the pathogenesis of Diabetes leading to increased lipid peroxide load in reflecting the severity of the disease and it also leads to renal insufficiency in this study represented by increased Creatinine levels.
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